目前对心血管参与风湿性免疫介导炎症性疾病的理解和管理
Maya H Buch1,2, Ziad Mallat3, Marc R Dweck4
1Centre for Musculoskeletal Research, Division of Musculoskeletal & Dermatological Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK. maya.buch@manchester.ac.uk.
Nature reviews. Rheumatology
|September 4, 2024
概括
免疫媒介性炎症性疾病 (IMID) 会增加心血管疾病的风险. 针对共享的炎症途径可能会改善结果,但需要更多的研究来有效诊断和治疗IMID患者的心脏问题.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫媒介性炎症性疾病 (IMIDs) 影响西方人口的高达10%,全球发病率不断增加.
- 心血管参与IMID,包括早发性动脉样性心血管疾病 (ASCVD) 和炎症性心肌病,增加死亡风险,并未得到充分承认.
- 共享的炎症机制将IMID和心血管疾病联系起来,这些研究得到了证据,证明ASCVD中免疫调节剂对心血管有好处.
研究的目的:
- 在风湿性IMID中审查当前对心血管病理中的炎症机制的理解.
- 讨论这些机制对IMIDs心血管参与的诊断和管理的影响.
- 强调心血管成像在风险分层,早期检测和预后方面的作用.
主要方法:
- 对IMIDs和心血管疾病的流行病学,临床和试验数据的文献综述.
- 关于共享炎症途径的概念的综合.
- 讨论诊断和治疗策略,包括心血管成像.
主要成果:
- 风湿性IMID与ASCVD和炎症性心肌病症等心血管疾病共享炎症途径.
- 免疫调节剂对心血管结果有希望,但疗效各不相同,IMID治疗炎症性心肌病的证据有限.
- 新兴的诊断协议和心血管成像技术为改善风险分层和管理提供了潜力.
结论:
- 了解共享的炎症机制对于解决IMIDs中的心血管风险至关重要.
- 针对性治疗和先进的心血管成像对于早期检测,风险分层和改善IMID患者心血管并发症的管理至关重要.
- 需要进一步的研究,以开发IMIDs的背景下炎症性心肌病的有效诊断和治疗策略.
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