杏仁体的连接性与青少年大脑认知发展 (ABCD) 研究®中的大量儿童样本中退缩/抑郁的行为有关
Elina Thomas1, Anthony Juliano2, Max Owens2
1Department of Psychiatry, University of Vermont Medical Center, 111 Colchester Avenue Burlington, VT, 05401, USA; Department of Psychology, Earlham College, 801 W National Rd, Richmond, IN 47374, USA.
Psychiatry research. Neuroimaging
|September 4, 2024
概括
识别早期的神经标志物用于儿童内化行为对于干预至关重要. 左桃体与听觉,前双和背部注意力网络的连接性与退缩/抑郁症状和社会行为有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 内化心理病理往往出现在青春期.
- 早期识别儿童期内化行为的神经标记可以促进及时干预.
- 青少年大脑和认知发展 (ABCD) 研究为此类研究提供了有价值的数据.
研究的目的:
- 调查皮质 - 杏仁功能连接和儿童内化行为之间的关联.
- 探索抑郁症,创伤事件和内化症状的多基因风险之间的关系.
- 为了识别退缩/抑郁和焦虑/抑郁行为的特定神经相关性.
主要方法:
- 利用了来自ABCD研究的6371名儿童 (9-11岁) 的数据.
- 分析了静止状态fMRI数据,以评估杏仁体与使用戈登分片的整个大脑感兴趣区域 (ROI) 的连接性.
- 采用线性混合效应模型来检查功能连接和父母报告的内化行为之间的关联 (儿童行为检查清单).
主要成果:
- 左桃体与听觉,前面对面网络 (FPN) 和背部注意网络 (DAN) 的连接ROI与退缩/抑郁症状显著相关.
- 杏仁体与DAN的连接与社会焦虑,社会障碍和社会问题有关.
- 杏仁体和FPN/听觉网络之间的连接与社会焦虑和社会问题相关.
结论:
- 皮层-杏仁功能连接模式与青春期前儿童的内化行为有关.
- 社交行为和相关的神经通路 (例如,杏仁体-DAN连接) 在检查抑郁症的大脑相关性时是重要的考虑因素.
- 这些发现突出了通过了解儿童时期内化症状的神经标志物的早期检测和干预的潜力.
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