友情火:由天生的免疫系统对自我进行识别
Veit Hornung1, Moritz M Gaidt2
1Gene Center and Department of Biochemistry, Ludwig Maximilians Universität, Munich, Germany.
Current opinion in immunology
|September 4, 2024
概括
天生的免疫系统可能会错误地激活对身体自身细胞的防御. 这种"友好的火"是免疫感知中固有的权衡,可能与衰老有关.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 天生的免疫系统通过模式触发免疫 (PTI) 和效应因子触发免疫 (ETI) 检测病原体.
- 最近,提出了损伤触发免疫 (DTI),将PTI扩展到包括自导危险信号 (DAMP).
- 然而,ETI在无菌炎症和DTI中的作用仍未得到充分探索.
研究的目的:
- 重新评估损害触发免疫 (DTI) 的基础机制.
- 要突出效应器触发免疫 (ETI) 途径在DTI中的低估作用.
- 提出一种新的框架,以理解先天免疫中的自我认知.
主要方法:
- 对PTI,ETI和DTI的现有数据进行概念分析和重新解释.
- 关于免疫感知,自我识别和对抗性类型的文献综述.
主要成果:
- 无论是PTI和ETI路径都容易产生错误的自我识别,称为"友好火".
- 这种错误激活不仅仅是由于模式识别,而且还涉及ETI路径.
- 免疫感应中的灵敏度-特异性权衡对这种现象有所贡献.
结论:
- 目前的DTI模型,专注于PTI和DAMP,忽视了ETI的关键参与.
- 错误的PTI和ETI通路的自我激活是天生的免疫的一个基本方面.
- 敌对的类型可能解释了进化对自我损伤的免疫反应的耐受性,这种反应在生命晚期表现出来.
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