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新开发的PANDAS/PANS问卷的可靠性和有效性

Akita Bleibach¹, Camilla Birgitte Sørensen¹, Liselotte Skov¹

¹Department of Paediatrics and Adolescents Medicine, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

|September 4, 2024

概括

一个新的问卷有效地选儿童自身免疫神经精神疾病的症状和并发症与链球菌感染 (PANDAS) 和儿童急性发作的神经精神疾病综合征 (PANS). 该工具有助于评估PANDAS/PANS患者的严重程度和治疗有效性.

科学领域:

儿科神经学儿科神经学
精神病学是一个精神病学.
自身免疫性疾病自身免疫性疾病

背景情况:

儿童自身免疫神经精神疾病与链球菌感染 (PANDAS) 和儿童急性发作的神经精神综合征 (PANS) 需要标准化的评估工具.
目前用于PANDAS/PANS症状,并发症和严重程度的查方法缺乏全面的验证.

研究的目的:

评估针对PANDAS/PANS.设计的新型问卷的可靠性和有效性.
建立一种标准化的方法来查PANDAS/PANS症状,评估严重程度,并测量日常生活障碍和治疗效果.

主要方法:

开发了一份27项PANDAS/PANS问卷,分为十个领域.
在65名患有PANDAS/PANS的儿童中,通过将PANDAS/PANS问卷与CY-BOCS,ADHD-RS和SDQ相关联来评估外部有效性.
通过将问卷单项与各自的领域相关联来确定内部有效性.

主要成果:

潘达斯/潘斯问卷显示了高度的内部一致性,与中度至强度的相关性.
外部有效性显示了与ADHD-RS和CY-BOCS的显著相关性 (r_{s ≥0.60),以及与SDQ的较弱相关性 (r_{s <0.40).}}

结论:

潘达斯/潘斯问卷是潘达斯/潘斯评估的有效和临床可行的工具.
这种经过验证的工具可以改善临床和研究环境中PANDAS/PANS患者的管理.
问卷有助于查症状,评估严重程度,并发症和日常生活障碍.

关键词:

神经心理疾病神经心理疾病儿科急性发作的神经精神综合征 (PANS)与链球菌感染相关的儿科自身免疫神经精神疾病 (PANDAS)问卷问卷问卷问卷选工具是一个选工具.

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