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发现具有因达或皮拉支架的选择性Orai通道阻塞剂

Elisa Liardo1, Anh-Tuan Pham1, Amanda F Ghilardi1

  • 1Center for Drug Discovery and Translational Research, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

European journal of medicinal chemistry
|September 4, 2024
PubMed
概括

研究人员开发了化合物4k,该化合物是释激活通道 (CRAC) 的选择性阻断剂. 这种分子为研究T细胞功能和相关免疫疾病提供了一个有前途的新工具.

关键词:
自身免疫性疾病是一种自身免疫性疾病.释放激活 (CRAC) 通道激活T细胞的核因子 (NFAT)耳朵的阻塞剂 耳朵的阻塞剂储存运行的入口 (SOCE)暂时的受体潜力 melastatin 4 和 7 (TRPM4 和 TRPM7) 道.

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