纳米疗法治疗瘤的进展,通过向的过载来治疗瘤
Chenglong Wang1, Junrong Peng2, Yiwei Xiao2
1Department of Pharmaceutical Sciences, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China; Department of Pharmacy, Yibin Hospital Affiliated to Children's Hospital of Chongqing Medical University, Yibin, Sichuan 644000, China.
Colloids and surfaces. B, Biointerfaces
|September 4, 2024
概括
过载策略为传统的癌症治疗提供了一个有希望的,低毒性的替代方案. 将基于的纳米粒子与PTT和PDT等疗法结合起来,可以提高抗瘤疗效.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 传统的癌症疗法在有效性和副作用方面面临局限性.
- 离子 (Ca2+) 在细胞过程中至关重要,但过载会诱导亡.
- 向过载是一种新的,低毒性的抗瘤方法.
研究的目的:
- 审查基于的纳米颗粒对外源Ca2+过载的研究.
- 为了总结内源的Ca2+过载策略.
- 探索组合疗法,以增强抗瘤效果.
主要方法:
- 基于的纳米粒子 (CaCO3,CaP,CaO2,HA) 的分类.
- 内生Ca2+过载策略的概述 (通道调节,膜破坏,酸度,氧化应激).
- 综合策略与PTT,PDT,CDT,SDT,ICD和气体治疗的综合策略的审查.
主要成果:
- 基于的纳米粒子为外源Ca2+过载提供了多种选择.
- 内生策略通过各种机制调节Ca2+稳态.
- 组合疗法通过向线粒体Ca2+过载来显著提高治疗效率.
结论:
- 基于过载的抗瘤策略显示出显著的前景.
- 利用瘤微环境的组合疗法提供了协同效应.
- 对新的目标和组合策略进行进一步的研究是有必要的.
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