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瓦尔酸可能有助于打击COVID-19:一项病例对照研究

O Moreno-Pérez¹, E Merino², J Manuel Ramos³

¹Endocrinology and Nutrition department, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain; Clinical Medicine Department, Miguel Hernández University, Elche, Spain.

|September 4, 2024

概括

酸 (VPA) 的使用,特别是在治疗范围内,与SARS-CoV-2感染发病率的显著减少有关. 这表明VPA可能具有抗病毒作用,因此需要进一步研究其在控制COVID-19中的作用.

科学领域:

病毒学病毒学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

早期证据表明,酸 (VPA) 可能具有抗病毒性质.
鉴于正在进行的COVID-19大流行,调查VPA对SARS-CoV-2感染的影响至关重要.

研究的目的:

为了比较SARS-CoV-2感染的发病率和严重程度,酸 (VPA) 用户与普通人群相比.
评估VPA对COVID-19的潜在保护作用.

主要方法:

在2020年3月1日至12月17日期间,在一个队列中进行了嵌套的病例控制研究.
确定了接受VPA的确诊的SARS-CoV-2感染患者,并与未暴露的普通人群进行了比较.
评估了VPA治疗方案 (全时或非全时) 和治疗范围 (ATR) 的水平.

主要成果:

与一般人口相比,VPA使用者的SARS-CoV-2感染发生率较低 (1.736%-1.910%vs. 2.201%).
在治疗范围 (ATR) 内的VPA水平的患者显示SARS-CoV-2感染风险降低了>75% (或0.233-0.218).
在VPA使用者中,COVID-19入院的发生率也较低 (OR0.543).

结论:

在治疗范围内使用酸 (VPA) 与SARS-CoV-2感染率的显著降低有关.
在接受VPA治疗的患者中,观察到降低COVID-19入院风险的趋势.
这些发现凸显了对VPA在COVID-19治疗和预防中的抗病毒潜力的进一步调查的必要性.

关键词:

瓦尔普罗伊克酸是一种酸.在 COVID-19 疫情中,西班牙西班牙西班牙西班牙西班牙西班牙住院的入院情况影响影响影响影响事件发生率事件发生率进入医院的医院.西班牙西班牙西班牙西班牙西班牙瓦尔酸是一种酸.

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