在急诊室经常使用的IV芬太尼是否会改变QT值? 一个前性的观察性研究
Ayşe Yekta Öztürk1,2, Ayfer Keleş3, Ahmet Demircan1
1Department of Emergency Medicine, Faculty of Medicine, Gazi University, Ankara, Türkiye.
BMC anesthesiology
|September 4, 2024
概括
芬太尼在急诊室的使用可以显著延长QT间隔,这是衡量心脏电活动的指标. 虽然没有发生危险的心律失常,但这种效应在高危患者中需要考虑.
科学领域:
- 心脏病学 心脏病学
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 芬太尼是急诊室 (ED) 中常见的阿片类止痛药.
- 它对QT间隔 (QTc) 的影响尚不清楚.
- 目前的做法往往涉及在没有QTc监测的情况下给予药物.
研究的目的:
- 为了研究静脉注射芬太尼对QTc间隔的影响.
- 为了确定芬太尼是否会导致QTc延长或缩短.
主要方法:
- 在ED中进行前性观察性研究.
- 109名患者接受了非输管手术的IV芬太尼.
- 在服用芬太尼之前和在服用芬太尼后多个时间点进行了ECG和QTc测量,最长为60分钟.
主要成果:
- 芬太尼尔的使用导致了统计学上显著的QTc延长.
- 最大的QTc延长发生在30分钟 (中位数增加13.08毫秒).
- 在40岁以上的女性患者中,QTc延长更为明显,但没有观察到恶性心律不整.
结论:
- 芬太尼显著延长了QTc间隔.
- 芬太尼的QTc延长效应应应考虑在易患Torsades de Pointes的患者中.
- 尽管具有统计学意义,但在本研究队列中没有观察到临床心律失常.
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