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饮食炎症指数和饮食总抗氧化能力与哈西莫托甲状腺炎之间的关联:一个病例对照研究
Sepideh Alijani1, Maliheh Ghadir2, Bahram Pourghassem Gargari3
1Student Research Committee, Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC endocrine disorders
|September 4, 2024
概括
富含抗氧化剂的饮食显著降低了哈西莫托甲状腺炎 (HT) 的风险,这是一种炎症状况. 虽然饮食炎症指数 (DII) 与HT风险没有显著关联,但饮食总抗氧化能力 (DTAC) 证明具有保护性.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 哈西莫托甲状腺炎 (HT) 是一种与氧化压力相关的炎症性自身免疫性疾病.
- 饮食因素,特别是抗炎和抗氧化特性,可能会影响HT的发展.
- 研究饮食炎症指数 (DII) 和饮食总抗氧化能力 (DTAC) 在HT中的作用至关重要.
研究的目的:
- 检查DII和DTAC与伊朗成年人哈西莫托甲状腺炎风险之间的关联.
- 为了确定饮食模式是否影响甲状腺自身免疫标记物.
主要方法:
- 一项基于医院的病例控制研究,涉及230名参与者 (115例,115例对照).
- 通过食物频率问卷 (FFQ) 评估饮食摄入量,以计算DII和DTAC得分.
- 多变量逻辑回归分析调整以考虑混因素.
主要成果:
- 与对照组相比,在HT组中观察到较高的DII水平和较低的DTAC水平.
- 增加的DTAC与降低的HT风险显著相关 (OR=0.47,P=0.043).
- DII与抗甲状腺过氧化酶抗体 (anti-TPO),甲状腺蛋白抗体 (TG-Ab) 和甲状腺刺激激素 (TSH) 呈现正相关性,而DTAC与甲状腺过氧化酶抗体 (anti-TPO) 呈现负相关性.
结论:
- 饮食总抗氧化能力 (DTAC) 显著降低了哈西莫托甲状腺炎的风险.
- 虽然饮食炎症指数 (DII) 与HT风险没有显著关联,但它与甲状腺抗体和TSH相关.
- 抗炎和抗氧化剂丰富的饮食可能会改善甲状腺功能,在未来的研究中需要进一步调查.
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