多发性硬化症的预后模型:临床整合的进展和挑战
Joachim Havla1,2, Kelly Reeve3, Begum Irmak On4
1lnstitute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, Munich, Germany. joachim.havla@med.lmu.de.
Neurological research and practice
|September 5, 2024
概括
由于疾病的异质性,预测多发性硬化症 (MS) 的进展具有挑战性. 一项系统性审查发现,目前的预后模型缺乏在MS治疗决策中常规临床使用的性能和验证.
科学领域:
- 神经学 神经学
- 炎症性疾病 炎症性疾病
- 生物统计学 生物统计学
背景情况:
- 多发性硬化症 (MS) 是一种具有重大健康和经济影响的慢性中枢神经系统炎症性疾病.
- 目前的临床实践缺乏验证的预后模型来预测多发性硬化症的异质性疾病过程.
- 使用各种统计和人工智能方法开发的现有预后模型,由于性能,可转移性和验证性差,其临床实用性有限.
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