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将石墨烯纤维添加到聚甲基甲酸对生物相容性和表面特性的影响
Ildefonso Serrano-Belmonte1, Francisco Javier Cascales-Pérez2, Virginia Pérez-Fernández3
1Assistant Professor, School of Dentistry, Faculty of Medicine, University Dental Clinic, Morales Meseguer General University Hospital, University of Murcia, Murcia, Spain.
The Journal of prosthetic dentistry
|September 5, 2024
概括
与石墨烯纤维聚甲基甲酸盐 (PMMA-G) 生物相容,可用于临时假肢,与标准PMMA相比,细胞活力或细胞亡没有显著差异. PMMA-G还表现出更好的表面特性,如更高的湿透性和更低的粗度.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 纳米技术 纳米技术
背景情况:
- 临时固定假肢使用材料,如聚甲基甲酸 (PMMA) 暂时的美学和功能.
- 由于PMMA具有机械的局限性,因此研究使用石墨烯纤维 (PMMA-G) 等纳米材料进行增强.
- 关于PMMA-G生物相容性的数据有限,需要进一步研究.
研究的目的:
- 评估PMMA与PMMA-G的体外生物相容性和细胞毒性作用.
- 评估PMMA和PMMA-G化物对牙周带干细胞 (PDLSC) 活力和亡的影响.
- 为了描述PMMA和PMMA-G的表面特性.
主要方法:
- 准备的PMMA和PMMA-G样本用于化剂提取.
- 暴露在PMMA和PMMA-G化物的连续稀释中的PDLSC.
- 量化细胞活力 (MTT测定) 和细胞亡 (Hoechst 33342染色) 在24,48,72小时.
- 分析材料表面的地形和湿特性.
主要成果:
- 在不同度和时间点之间,PMMA,PMMA-G和对照组之间没有观察到细胞活力或细胞亡的统计学上显著差异.
- 对比分析显示,PMMA和PMMA-G化物之间没有显著的细胞毒性差异.
- 与PMMA相比,PMMA-G表现出较低的表面粗度和更高的湿透性.
结论:
- 无论是PMMA还是PMMA-G都是用于牙科应用的生物相容材料.
- PMMA-G与PMMA具有相似的生物相容性,具有增强的表面性能.
- 这些发现支持PMMA-G作为临时假肢的有希望的替代或改进材料.
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