一种食物对抗4种食物消除饮食对于儿科异性食道炎:一个多站点随机试验
Kara L Kliewer1, J Pablo Abonia1, Seema S Aceves2
1Division of Allergy and Immunology, Department of Pediatrics Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
The Journal of allergy and clinical immunology
|September 5, 2024
概括
一种4种食物的消除饮食比1种食物的饮食有所改善,对儿科异敏性食道炎 (EoE) 的症状有适度的改善. 然而,这两种饮食都显示出类似的组织学,内镜和生活质量结果,使得1食物饮食成为更简单的选择.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 儿科医学 儿科医学
背景情况:
- 对于儿科异性食道炎 (EoE) 的6种食物消除饮食在坚持和影响生活质量 (QoL) 中提出了挑战.
- 需要更少的限制性饮食干预措施来平衡儿科EoE管理中的疗效和QoL.
研究的目的:
- 为了比较1食物消除饮食 (1FED) 与4食物消除饮食 (4FED) 在儿科EOE的疗效.
- 为了评估症状改善,组织学缓解,内镜严重性,转录组变化和EoE接受饮食治疗的儿童的QoL.
主要方法:
- 一个多站点的随机比较试验,涉及63名儿科患者 (6-17岁) 具有活跃的EoE.
- 患者被随机分配到1FED (牛奶) 或4FED (牛奶,蛋,小麦,大豆) 在12周内.
- 主要终点:症状改善 (儿科埃索诺菲尔性食管炎症状评分);二级终点:组织学缓解,内镜评分,转录组和QoL.
主要成果:
- 与1FED (-14.5;P=.04) 相比,4FED显示出更大的平均症状改善 (PEESS: -25.0).
- 缓解率 (41%对44%),组织学评分,内镜评分和QoL在1FED和4FED组之间是相似的.
- 4FED的提款率 (32%) 比1FED (11%) 高.
结论:
- 虽然4FED提供了适度的症状改善,1FED显示了可比的组织学,内镜,QoL和转录组结果.
- 一种食物消除饮食是一种可行的,更简单的儿科EoE的第一线治疗方法,因为它的耐受性和有效性.
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