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晚年抑郁症与自杀念头的气味识别功能障碍.

Danyan Xu1, Ben Chen2, Mingfeng Yang2

  • 1The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Geriatric Neuroscience Center, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.

Journal of affective disorders
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概括

晚年抑郁症和自杀念头的老年人表现出臭味识别功能受损. 这种嗅觉功能障碍可能有助于识别自杀风险,并与较差的认知功能有关.

关键词:
认知功能 认知功能晚年生活中的抑郁症.气味识别 气味识别 气味识别自杀的想法 自杀的想法

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.
  • 精神病学是一个精神病学.

背景情况:

  • 老年人中自杀率更高,晚年抑郁症 (LLD) 是一个重要的危险因素.
  • 在LLD中早期识别自杀念头是具有挑战性的.
  • 在LLD中常见的气味识别 (OI) 功能障碍可能作为自杀念头的早期标志物.

研究的目的:

  • 为了比较具有 (LLD-S) 和没有 (LLD-NS) 自杀念头的LLD患者之间的OI.
  • 检查OI与LLD患者认知功能之间的关系.
  • 调查OI作为LLD中自杀风险的潜在查工具.

主要方法:

  • 这是一项涉及262名LLD-NS患者,63名LLD-S患者和316名健康老年人 (HOA) 的横截面研究.
  • 参与者接受了气味识别测试,标准化临床采访和全面的神经心理评估.
  • 评估的认知领域包括全球认知,处理速度,记忆,语言,执行功能和视觉空间能力.

主要成果:

  • 与LLD-NS患者和HOA患者相比,LLD-S患者的OI得分明显较低,认知表现较差.
  • 观察到自杀念头和OI功能障碍之间的互动效应,影响信息处理速度和视觉空间能力.
  • 在LLD-NS和LLD-S组之间,OI功能障碍调解了认知差异,突出了它在与自杀念头相关的认知缺陷中的作用.

结论:

  • 与LLD-NS患者和HOA患者相比,LLD-S患者的气味识别能力更差.
  • OI测试显示承诺作为一种有价值的工具,用于识别LLD的自杀念头和查自杀风险.
  • 在LLD中,OI损伤和自杀念头的同时发生与认知表现下降有关.