瘤衍生的免疫球蛋白样转录4通过诱导血管生成模仿通过MAPK/ERK信号在肝细胞癌的诱导术后复发促进
Jiayan Li1, Xiaofeng Ding2, Wanping Yan3
1Clinical Research Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
The American journal of pathology
|September 5, 2024
概括
免疫球蛋白样转录4 (ILT4) 在肝细胞癌 (HCC) 中促进血管仿真 (VM),导致瘤复发. 准ILT4及其MAPK/ERK通路可能为HCC提供新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 传统的抗血管生成药物在治疗肝细胞癌 (HCC) 的有效性有限.
- 血管造影 (VM) 是一种与血管生成不同的瘤生存机制,与恶性瘤的预后不佳有关.
- 免疫球蛋白样转录4 (ILT4) 的作用,一个已知的免疫反应调节器,在HCC内的VM中仍然未定义.
研究的目的:
- 研究ILT4在调节肝细胞癌 (HCC) 中血管仿真 (VM) 的作用.
- 阐明在HCC中ILT4介导VM的潜在分子机制.
- 探索ILT4作为抑制HCC进展和复发的潜在治疗标.
主要方法:
- 对HCC组织中VM和ILT4表达的分析,将发现与患者复发率相关联.
- 试验室研究涉及HCC细胞系中ILT4的过度表达和淘汰,以评估VM标记物,管形成,迁移和入侵.
- 调查ILT4诱导的VM中的基激活蛋白激酶 (MAPK) /ERK信号通路.
主要成果:
- 在手术后5年内复发的患者的HCC组织中,VM和ILT4表达显著丰富.
- 在HCC中,ILT4表达水平和VM密度之间观察到正相关性.
- ILT4调节的VM相关标记物,3D管形成,以及通过MAPK/ERK通路作用于HCC细胞系的细胞迁移/入侵.
结论:
- 在肝细胞癌 (HCC) 中,ILT4促进血管仿真 (VM),有助于术后复发.
- 涉及MAPK/ERK信号的ILT4介导VM通路,为HCC治疗提供了一个新的治疗点.
- 向ILT4可能提供一种抑制HCC血管生成和预防瘤复发的策略.
更多相关视频
相关概念视频
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K


