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无接触扩散反射光谱检测突液样本,以快速识别感染
Erin E Drewke1, Robert L Brand2, Caroline G Geels2
1Department of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas, USA.
Journal of biophotonics
|September 5, 2024
概括
扩散反射光谱 (DRS) 为诊断关节感染提供了一种快速,非接触式的方法. 该技术分析注射器中的突液,显示受感染和未受感染样本之间的显著差异.
科学领域:
- 生物医学光学 生物医学光学
- 医学诊断 医学诊断 医学诊断
- 传染性疾病 传染性疾病
背景情况:
- 败血性关节炎和其他严重的关节感染需要快速诊断.
- 及时识别关节感染对于迅速的手术干预至关重要.
研究的目的:
- 开发和评估一种非接触式扩散反射光谱 (DRS) 系统.
- 评估系统快速确定关节感染的能力.
主要方法:
- 使用光密的注射器持有器和光纤探针进行非接触式DRS测量.
- 从注射器中的18名患者的突液样本中获得的扩散反射频谱 (475655nm).
- 计算的反射率 (R 490/R 600和R 580/R 600) 进行了计算.
主要成果:
- 在受感染和未受感染的关节液样本之间的反射率中观察到统计学上显著的差异 (p < 0.05).
- R 490/R 600比率与白细胞 (WBC) 计数有显著的相关性.
- R 580/R 600比率显示与红细胞 (RBC) 计数有显著的相关性.
结论:
- 扩散反射光谱显示出作为关节感染的快速,非接触式诊断工具的希望.
- 开发的DRS系统可以区分受感染和未受感染的突液.
- 反射率与关键的临床生物标志物相关,支持诊断潜力.
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