在癌症进展中,阿佩林和非编码RNA之间的相互相互作用
Abdollah Jafarzadeh1,2,3, Bahar Naseri4, Hossein Khorramdelazad3
1Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Cell biochemistry and function
|September 5, 2024
概括
阿佩林和非编码RNAs (ncRNAs) 在癌症中具有双向关系,影响瘤生长和进展. 了解这种交叉通话为各种癌症提供了新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因规则 基因规则
背景情况:
- 阿佩林是APJ的配体,在癌症中过度表达,促进了癌症的增殖,迁移,血管新生,转移和免疫逃避.
- 非编码RNAs (ncRNAs),包括lncRNAs,circRNAs和miRNAs,是基因表达的关键调节者,在癌症中扮演着新兴的角色.
- 越来越多的证据表明,在瘤发生的背景下,阿佩林和ncRNA之间存在复杂的,双向的交叉通话.
研究的目的:
- 阐明各种癌症类型中阿佩林和ncRNAs之间的复杂双向相互作用.
- 提供对这种交叉通话背后的分子机制的见解.
- 探索在癌症治疗中准阿佩林-ncRNA轴的潜在治疗影响.
主要方法:
- 文献综述和现有关于癌症中阿佩林和ncRNA相互作用的研究的综合.
- 分析详细研究miRNA向阿佩林mRNA及其对瘤生长的影响.
- 检查关于特定的lncRNAs和circRNAs如何调节不同癌症中的阿佩林表达的研究.
主要成果:
- 几个miRNAs (例如,miR-224,miR-195-5p,miR-204-5p) 直接准阿佩林mRNA,抑制其表达并抑制前列腺癌,肺癌和HCC等癌症的瘤生长.
- 一些ncRNAs,包括circ-NOTCH1,circ-ZNF264和lncRNA BACE1-AS,在胃癌,质瘤和HCC中升调阿佩林表达.
- 阿佩林信号还可以影响ncRNAs的表达,例如circ_0000004/miR-1303,miR-15a-5p和miR-106a-5p,影响骨髓瘤,肺癌和前列腺癌的瘤发生.
结论:
- 阿佩林和ncRNAs之间的交叉是癌症发展和进展的重要因素.
- 针对这种双向相互作用,为新型癌症疗法提供了一个有希望的途径.
- 对这种交叉声的分子机制的进一步研究可能会导致更有效的治疗策略.
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