在乙醇上Limosilactobacillus fermentum的降解效应和机制
Lingling Zhang1,2, Yuhong Zhang3, Shijian Liu1,2
1College of Food Science, Southwest University, Chongqing, China. jiajias@swu.edu.cn.
Food & function
|September 5, 2024
概括
一种新型益生菌Limosilactobacillus fermentum DACN611,有效降解乙醇,并防止酒精引起的肝损伤. 这项研究阐明了其机制,为管理酒精消费影响提供了潜在的解决方案.
科学领域:
- 微生物学 微生物学
- 生物技术是生物技术.
- 毒理学 毒理学 毒理学
背景情况:
- 急性重度饮酒会引起诸如头和肝损伤等不良影响.
- 乳酸细菌可以降解乙醇,但根本的机制尚未完全理解.
研究的目的:
- 识别和表征一种具有优越乙醇降解能力的乳酸细菌菌株.
- 阐明这种菌株降解乙醇并防止酒精毒性的机制.
- 在急性重度饮酒小鼠模型中评估该菌株的安全性和有效性.
主要方法:
- 对五十种乳酸细菌菌株进行乙醇降解的选.
- 在乙醇压力下对所选菌株 (Limosilactobacillus fermentum DACN611) 的转录组分析.
- 对胃酸和胆汁盐的抗应变能力的评估.
- 在急性重度饮酒的昆明小鼠模型中进行评估,测量生理和生化参数.
主要成果:
- 在实验室中,Limosilactobacillus fermentum DACN611显示了90%以上的乙醇减少.
- 转录组分析显示,乙醇通过细胞周期调整,蛋白质合成,代谢平衡以及细胞壁/膜调节而降解.
- 在体内,DACN611增加了置反射损失的延迟和缩短的持续时间,降低了血清乙醇和乙,增强了酒精脱酶 (ADH) 和乙脱酶 (ALDH) 活动,并减少了肝损伤标志物.
结论:
- Limosilactobacillus fermentum DACN611通过适应性代谢变化具有显著的乙醇降解能力.
- 这种菌株促进ADH和ALDH活动,为酒精诱导的肝损伤提供保护.
- DACN611是一种有前途的益生菌,在减轻急性酒精不良影响方面已证明其安全性和有效性.
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