赖诺病毒循环值,病毒共检测和临床疾病严重程度在患有并发症和没有并发症的儿童之间的相互依赖
María Isabel Sánchez Códez1, Isabel Benavente Fernández2,3,4, Katherine Moyer5
1Division of Pediatric Infectious Diseases, Puerta del Mar, Cadiz, Spain.
在儿童中,犀牛病毒 (RV) 感染很常见. 较高的RV病毒载荷和单个RV感染,而不是共同检测,与年龄较大和住院风险增加有关.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 临床研究 临床研究
背景情况:
- 犀牛病毒 (RVs) 是儿童急性呼吸道感染 (ARI) 的主要原因.
- RV病毒载荷 (VL) 和病毒共同检测对疾病严重性的影响尚不清楚.
研究的目的:
- 调查RV病毒载荷,病毒共检测和儿科RV-ARI中的临床结果之间的关联.
- 确定预测RV-ARI儿童疾病严重程度的因素.
主要方法:
- 从2011-2013年对1899名患有RV-ARI的儿童和青少年 (≤21岁) 的回顾性研究.
- 通过PCR循环值 (CT) 分层的RV病毒载荷 (VL) (高 ≤25,中等 26-32,低 >32).
- 调整后的分析评估了RV VL和共检测对住院,氧气需求,PICU护理和住院时间的影响.
主要成果:
- 78%的儿童患有慢性并发症;24%的儿童有病毒共同检测.
- 单一的RV感染显示出更高的VL,与联合感染相比,与年龄更大有关.
- 随着RV VL的增加,病毒共检测率下降.
- 潜在条件独立预测了更糟糕的结果;高RV VL预测了PICU护理;单个RV-ARI预测了住院治疗.
结论:
- 单一的RV感染与儿童的病毒载荷较高和年龄较大有关.
- 潜在的疾病是儿科RV-ARI中严重临床结果的最强有力的预测因素,超过病毒载量或共同检测.
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