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长期胃肠道发病率在患有胃症的患者出生:一个基于国家登记的队列研究
Cecilia Caldeman1, Anna Fogelström1, Tomas Wester1
1Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Journal of pediatric gastroenterology and nutrition
|September 5, 2024
概括
与简单病例相比,患有复杂胃的儿童面临着显著更高的肠衰竭和肠道阻塞的风险. 这些并发症主要表现在生命的头两年内.
科学领域:
- 儿科手术 儿科手术
- 新生儿护理 新生儿护理
- 胃肠病学 胃肠病学
背景情况:
- 胃分裂涉及肠道暴露于羊水,可能会危及血液供应并造成不同程度的损伤.
- 复杂的胃症的特征是严重的并发症,如肠道缩,卷积,缩和穿孔.
研究的目的:
- 为了调查长期的胃肠道发病率在胃.
- 为了比较简单和复杂的胃病例之间的结果.
主要方法:
- 全国范围的回顾性队列研究,使用瑞典国家登记册.
- 包括1997年1月1日至2016年12月31日期间出生的所有患有胃症的儿童.
- 评估的主要结局是肠道衰竭和肠道阻塞,复杂的胃作为暴露.
主要成果:
- 该研究包括315例胃病例 (260例简单病例,55例复杂病例),随访时间中位数为8年.
- 复杂的胃显著增加了肠道衰竭 (HR: 11.7) 和肠道阻塞 (HR: 4.3) 的风险.
- 9%的复杂病例需要为肠道衰竭进行重建性手术,而在简单病例中没有;18.2%的复杂病例需要为阻塞进行手术,而在简单病例中只有6.9%.
结论:
- 复杂的胃带来了长期胃肠道疾病的风险,包括肠道衰竭和肠道阻塞.
- 大多数这些不良胃肠道事件发生在出生后的头两年内.
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