识别PI3K-AKT途径相关基因和构建ccRCC的预后预测模型
Shaowen Hu1, Xiaoli Zhang1, Huiru Xin2
1Department of Urinary Surgery, Huaihe Hospital of Henan University, Kaifeng, China.
Cancer reports (Hoboken, N.J.)
|September 5, 2024
概括
三个PI3K-Akt通路基因 (IL2RG,EFNA3,MTCP1) 可以预测清细胞细胞癌 (ccRCC) 的存活率. 这些生物标志物可以改善ccRCC诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 清细胞细胞癌 (ccRCC) 的预后随着阶段的增加而恶化.
- 在ccRCC和其他癌症中,PI3K-Akt通路经常失调.
- 针对PI3K-Akt路径为ccRCC提供了一个有希望的治疗策略.
研究的目的:
- 确定与ccRCC诊断和预后相关的关键PI3K-Akt通路基因.
- 使用TCGA和GEO数据集的数据挖掘来进行基因识别.
- 开发生物标志物,以改善ccRCC患者管理.
主要方法:
- 对TCGA和GEO数据集的生物信息学分析以确定差异表达基因 (DEG).
- 通过KEGG路径分析,确定PI3K-Akt信号路径中的DEG.
- 卡普兰-梅尔分析和SPSS评估基因存活关联并构建预后模型.
主要成果:
- 在GEO和TCGA数据库中发现了911个高度表达的基因.
- 在PI3K-Akt信号通路中,有42个基因被丰富.
- 使用IL2RG,EFNA3和MTCP1表达的多基因模型预测了ccRCC存活率.
结论:
- 三个与PI3K-Akt通路相关的基因 (IL2RG,EFNA3,MTCP1) 显示出对ccRCC预后预测的潜力.
- 这些基因可能有助于阐明ccRCC的分子特征.
- 鉴定到的生物标志物可以为改善治疗方案和临床应用提供信息.
关键词:
在 EFNA3 中,EFNA3 是 EFNA3 的代码.在 IL2RG 中, IL2RG 是 IL2RG.在MTCP1中,MTCP1是MTCP1.生物信息学是一种生物信息学.清细胞细胞癌是什么?预测模型的预测模型.的PI3K-Akt信号通路.更多相关视频
13:34A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
10.2K
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
1.2K
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Cancer-Critical Genes I: Proto-oncogenes
8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
