在一个高死亡率的流行病期间,对印度牛群中块性皮肤病病毒的病理,免疫和分子流行病学分析
Gundallhalli Bayyappa Manjunathareddy1, Mani Saminathan2, Lalasangi Sanjeevakumar3
1ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Bengaluru, Karnataka, India.
The veterinary quarterly
|September 5, 2024
概括
最近在印度爆发的结块性皮肤病 (LSD) 疫情导致了由于一种新型病毒性LSD病毒 (LSDV) 菌株的高死亡率. 这种菌株导致牛和水牛的全身感染,突出显示需要更新的控制策略.
科学领域:
- 兽医病毒学 兽医病毒学
- 流行病学 流行病学
- 分子生物学分子生物学
背景情况:
- 块状皮肤病 (LSD) 是一种新兴的病毒威胁,对牛和水牛造成重大经济损失.
- 最近在印度发生的LSD疫情显示出异常高的死亡率,促使进一步调查.
研究的目的:
- 调查印度近期突发性皮肤病 (LSD) 流行期间高死亡率的原因.
- 描述涉及的LSD病毒 (LSDV) 的流行病学,病理学和遗传特征.
主要方法:
- 在70个疫情中检查了1618只动物;对48头牛进行了尸检.
- 评估疾病阶段,病变分布,组织和血液中的病毒载量,细胞因子表达和亡基因通路.
- 对LSDV分离物进行基因分析.
主要成果:
- 记录的发病率 (31.70%),死亡率 (2.97%) 和病例死亡率 (9.37%) 的比率.
- 尸体检查显示,内部器官中存在全身性感染,内结核;病毒载量在皮肤,气管,舌头和淋巴结中最高.
- 基因分析发现了一种具有独特突变的新型,高度毒性LSDV菌株,可能起源于肯尼亚.
结论:
- 印度LSD流行病的高死亡率归因于一种新发现的,高度毒性LSDV菌株,导致全身性疾病.
- 这些发现强调了LSDV的演变以及需要加强监测和控制措施的必要性.
关键词:
免疫组织化学 免疫组织化学块性皮肤病是一种皮肤疾病.灭症 (apoptosis) 是一种死亡的过程.这里是牛群.临床症状 临床症状 临床症状大致病理学是严重的.组织病理学 组织病理学阶段化 阶段化更多相关视频
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