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有三例不常见的与药物相关的骨骨硬化病例
Hunter VanDolah1, Jason R Crossley2, H Jeffrey Kim2
1Georgetown University School of Medicine Washington DC USA.
World journal of otorhinolaryngology - head and neck surgery
|September 5, 2024
概括
与药物相关的骨骨缩是罕见的,与抗吸收和氨酸激酶抑制剂药物有关. 手术重建可以在保守治疗失败时解决症状.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与药物相关的骨骨缩是一种罕见的疾病.
- 它主要与抗吸收和生物药物有关.
- 这项研究介绍了与氨酸激酶抑制剂相关的外部听觉通道 (EAC) 骨髓缩.
研究的目的:
- 报告一系列外部听道 (EAC) 骨髓缩的病例.
- 为了调查特定药物和EAC骨髓缩之间的关联.
- 为了评估EAC骨髓缩的治疗结果.
主要方法:
- 追溯的案例系列.
- 对3名患有EAC骨 necrosis的患者进行了审查.
- 对药物史的分析,包括抗吸收剂和氨酸激酶抑制剂.
- 评估手术和保守的管理策略.
主要成果:
- 案例1:一名患有骨质疏松症的84岁女性接受了德诺苏马布和赖塞德罗尼酸治疗,患有双边EAC骨硬化,并通过左侧EAC重建成功治疗.
- 案例2:一个69岁的患有骨质疏松症的男性接受了阿伦德罗尼酸和佐勒德罗尼酸的治疗,右侧EAC骨硬化得到了保守的管理.
- 案例3:一个60岁的男性患有慢性骨髓性白血病,接受了伊马替尼 (一种铁激酶抑制剂) 治疗,经过手术重建后,右EAC骨硬化症得到了解决.
结论:
- 抗吸收剂和氨酸激酶抑制剂可以调节骨重塑,导致罕见的骨骨.
- 当保守的管理失败时,死骨的外科切除和EAC重建可以解决症状.
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