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Updated: Jun 14, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
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Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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使用核酸转糖酶-2的2'-脱氧核糖核酸类型的格拉姆尺度酶合成

Admir Salihovic1,2, Alex Ascham3, Andrea Taladriz-Sender1,2

  • 1Department of Pure & Applied Chemistry, University of Strathclyde 295 Cathedral Street Glasgow UK G1 1XL glenn.burley@strath.ac.uk.

Chemical science
|September 5, 2024
PubMed
概括

这项研究引入了一种使用Lactobacillus leichmannii核酸2'-脱氧核糖转移酶 (LlNDT-2) 合成改性2'-脱氧核糖核酸的化学酶方法. 优化在水中的工艺使得有价值的类似物能够在克尺度上生产出来.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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