系统性硬化症中的循环细胞粘附分子:系统性审查和元分析
Arduino A Mangoni1,2, Angelo Zinellu3
1Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, SA, Adelaide, Australia.
Frontiers in immunology
|September 5, 2024
概括
系统性硬化症患者表现出高水平的特定细胞粘附分子,包括ICAM-1,VCAM-1,PECAM-1,E-selectin和P-selectin. 这些分子可以作为评估SSc.心血管风险的有价值的生物标志物.
科学领域:
- 心血管研究研究心血管研究
- 类风湿病学 类风湿病学
- 生物标志物发现发现
背景情况:
- 患有全身性硬化症 (SSc) 的患者面临内皮功能障碍,动脉样硬化和心血管事件的风险增加.
- 确定内皮功能障碍和动脉动脉生成的可靠生物标志物对于SSc的早期心血管风险管理至关重要.
研究的目的:
- 系统地审查和对循环细胞粘附分子作为SSc.生物标志物的研究进行元分析.
- 研究SSc与参与内皮功能障碍和动脉生成的各种细胞粘附分子水平之间的关联.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行了全面的搜索,截至2024年5月1日.
- 偏差风险和证据确定性是使用既有工具来评估的.
- 对来自43项符合条件的研究的数据进行了元分析.
主要成果:
- 与对照组相比,在SSc患者中观察到ICAM-1,VCAM-1,PECAM-1,E-selectin和P-selectin的血度显著更高.
- 中等确定性证据支持ICAM-1,VCAM-1和E-selectin的升高;PECAM-1和P-selectin的低至非常低的确定性.
- 对于L-选择素,没有发现显著差异,对于其他分子,数据有限.
结论:
- 循环中的ICAM-1,VCAM-1,PECAM-1,E-selectin和P-selectin显示出作为内皮功能障碍和SSc中的动脉生成生物标志物的潜力.
- 这些生物标志物可能有助于系统性硬化症患者的心血管风险评估.
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