短期HIIT对瘦身,肥胖和糖尿病患者的HDL功能有不同的影响
Lin Zhu1,2, Julia An2, Thao Luu2
1Tennessee Valley Health System, Veterans Affairs, Nashville, TN, United States.
Frontiers in physiology
|September 5, 2024
概括
高强度间歇训练 (HIIT) 提高了所有受试者的高密度脂蛋白 (HDL) 抗氧化能力. 然而,HDL胆固醇和排泄能力的改善是特定于瘦个体的,这表明运动对心血管健康的影响取决于背景.
科学领域:
- 运动生理学 运动生理学
- 心血管健康 心血管健康
- 脂质代谢 脂质代谢是什么
背景情况:
- 高密度脂蛋白 (HDL) 通过抗氧化能力和胆固醇流动对心血管保护至关重要.
- 运动训练对HDL功能的影响仍然不完全理解,尽管已知对降低三糖醇 (TG) 的影响.
- 以前的研究表明,短期高强度间歇训练 (HIIT) 可以改善胰岛素敏感性,但不能改善胰岛素抵抗个体的炎症.
研究的目的:
- 为了评估短期HIIT计划对HDL功能的影响.
- 为了评估瘦肉,肥胖的非糖尿病患者和肥胖的2型糖尿病患者 (T2DM) 之间脂蛋白的变化.
- 为了研究HDL功能和运动后代谢背景之间的关系.
主要方法:
- 所有参与者都接受了监督的15天HIIT计划 (每天40分钟).
- 在训练前和训练后测量了心肺呼吸能力 (VO2峰值).
- 在干预之前和之后,分析了禁食血液样本以检测脂质概况和HDL功能.
主要成果:
- 在肥胖和T2DM患者中,HIIT改善了血脂概况.
- 高脂胆固醇水平和胆固醇外流能力仅在瘦人群中增加.
- 在所有参与者群体 (瘦,肥胖,T2DM) 中,HDL抗氧化能力有所改善.
- 高脂抗氧化能力的变化与异位性脂质和高脂-TG含量相反相关.
结论:
- 短期HIIT以代谢依赖的方式增强HDL功能,与改善的脂质样本相关.
- 该研究强调,HDL颗粒中的TG含量可能会对HDL的抗atherogenic特性产生负面影响.
- 运动干预可以调节HDL功能,根据个体的代谢状态产生不同的影响.
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