量身定制的运动方案对体力能力和血蛋白质组概况在COVID-19后状态下的影响
Mohammad Mobarak H Chowdhury1, Marie-Noelle Fontaine2,3, Sarah-Eve Lord2,3
1Department of Immunology and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Frontiers in physiology
|September 5, 2024
概括
监督运动可以改善COVID后病情 (PCC) 患者的身体能力和幸福感,而不会导致疲劳恶化. 这项研究监测了运动对PCC个体身体能力,症状和分子标志物的影响.
科学领域:
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 后COVID状态 (PCC) 的特点是持续的疲劳和后劳动不适 (PEM).
- 目前的建议经常建议不要炼,尽管有新兴证据支持其益处.
- 本研究研究了结构化炼计划对PCC患者的影响.
研究的目的:
- 评估一个为期8周的混合运动计划对PCC患者身体能力和症状的影响.
- 评估该计划对疲劳,全身氧化应激和血蛋白质组形状的影响.
- 确定PCC患者适应性运动的安全性和有效性.
主要方法:
- 25名PCC患者被分为运动 (n=15) 和非运动 (n=10) 组;包括一个没有PCC的对照组.
- 运动干预包括心血管和抵抗训练,对疲劳相对强度进行监测.
- 测量包括身体能力测试,症状评估,疲劳水平和血/PBMC生物标志物的分析 (谷氨,脱氧氨,蛋白质).
主要成果:
- 与不运动组相比,运动组在Bicep Curl和Sit-to-Stand测试中显示出显著的改善.
- 增加了体力活动水平,提高了日常功能,而不会对疲劳产生不良影响.
- 在女性参与者中,Glutathione水平增加,而血蛋白质组学揭示了运动组的炎症蛋白减少.
结论:
- 监督,适应疲劳的运动是安全有效的,可以改善PCC患者的身体能力和福祉.
- 血蛋白质组学和氧化应激标记可以客观地监测PCC的物理改善.
- 需要进一步进行大规模研究,以确定可靠的分子标记物用于患者监测.
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