治愈性胃切除术后患者血清肌素轻微变化的临床结果:一项前性研究
Wen-Tao Cai1, Xiu-Ya Zeng2, Yun-Shi Huang1
1Department of Traumatic Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in oncology
|September 5, 2024
概括
术后血清肌素 (SCr) 降低可能会防止并发症,而SCr升高表明胃癌 (GC) 患者患有严重问题的风险. 预测性名录图有助于识别高风险个体.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术瘤学手术瘤学
- 医学统计 医学统计
背景情况:
- 患有功能衰竭的患者面临手术后并发症 (PC) 的增加.
- 手术后血清肌素 (SCr) 变化可以表明功能状态.
- 胃癌 (GC) 手术具有固有的并发症风险.
研究的目的:
- 在胃癌 (GC) 患者中调查血清肌素 (SCr) 变化和术后并发症 (PCs) 之间的关联.
- 在接受手术的GC患者中确定PC的预测因子.
- 开发一种预测模型,用于识别PC风险较高的患者.
主要方法:
- 对530名GC患者手术前和手术后的SCr水平 (2014-2016) 的前性数据收集.
- 患者分为降低 (<10%),正常 (10%) 或升高 (>10%) 的SCr变化组.
- 使用R语言进行单变量,多变量物流分析和名ogram构造.
主要成果:
- 降低的SCr与较低的PCs相关,而升高的SCr独立预测了严重的术后并发症 (SPC).
- 诸如术后SCr变化,年龄,低albuminemia,全胃切除,联合切除和腹腔镜等因素与PCs有关.
- 结合这些因素的预测模型实现了PC预测的c指数为0.715.
结论:
- 减少术后SCr作为PCs的保护因素.
- 术后SCr升高是SPC的独立风险因素.
- 开发的诺米图有效地识别了PCs高风险的GC患者.
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