铁和缺乏症与口腔口炎之间的关系:系统性审查和元分析
Nakisa Torabinia1, Saba Asadi2, Mohammad J Tarrahi3
1Department of Oral and Maxillofacial Pathology, Dental Materials Research Center, Dental Research Institute, School of Dentistry Isfahan University of Medical Sciences, Isfahan, Iran.
复发性口腔炎 (RAS) 与较低的铁和水平有关. 这次系统性审查发现,与健康人相比,RAS患者的血清铁和含量显著降低.
科学领域:
- 口腔医学是指口腔医学.
- 营养科学 营养科学
- 系统审查是系统的审查.
背景情况:
- 复发性口腔口腔炎 (RAS) 是一种常见的口腔粘膜性疾病.
- RAS的病因是多因素的,并未完全理解.
- 调查微量营养素缺乏和RAS之间的潜在联系对于了解其病变产生至关重要.
研究的目的:
- 系统地审查和对现有研究进行元分析,研究铁和缺乏与复发性口腔口炎 (RAS) 的发生之间的关系.
- 量化血清中铁和含量与RAS患病率之间的关联.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 在主要的国际和波斯数据库中进行全面的电子搜索.
- 使用纽卡斯尔-太华尺度 (NOS) 评估研究资格;使用综合元分析 (CMA) 软件分析数据.
主要成果:
- 在选了1383个初始记录后,最终的元分析包括了22篇文章.
- 在RAS患者中观察到铁的显著标准化平均差异为-0.421和的-0.955.
- 具体分析显示,男性 (-0.309) 和女性 (-0.483) RAS患者的铁含量较低.
结论:
- 与健康对照组相比,患有复发性口腔口腔炎 (RAS) 的患者的血清铁含量显著降低.
- 较低的血清水平也与RAS的存在有显著的关联.
- 这些发现表明,铁和缺乏可能在RAS的发展或恶化中发挥作用.
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