牙周病与Covid-19的严重程度之间的关系的建议机制:常见的病原体,炎症媒介和危险因素
Elham Keykha1, Leila Khodadadifard2, Mahdieh-Sadat Moosavi3
1Department of Oral and Maxillofacial Medicine, Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Advanced biomedical research
|September 5, 2024
概括
牙周病 (PD) 可能会使COVID-19的结果恶化. 本综述探讨了口腔病原体,糖尿病等共同风险因素,以及这两种情况中炎症增加之间的联系,影响疾病严重程度.
科学领域:
- 口腔健康和传染病
- 免疫学和炎症 免疫学和炎症
- 公共卫生和流行病学
背景情况:
- 牙周病 (PD) 是一种与全身风险因素相关的慢性炎症状况.
- 2019年冠状病毒疾病 (COVID-19) 涉及细胞因子风暴,并与PD共享风险因素.
- 了解口腔健康和病毒感染之间的相互作用对公共卫生至关重要.
研究的目的:
- 审查和评估牙周病 (PD) 和COVID-19之间的潜在关系.
- 确定连接PD和COVID-19的常见病理生理机制和危险因素.
- 评估PD对COVID-19严重程度和预后的影响.
主要方法:
- 在PubMed和谷歌学者进行了全面的文献搜索.
- 关键词包括COVID-19,SARS-CoV-2,牙周病 (PD) 和呼吸道疾病.
- 审查的重点是研究口腔病原体,病毒存在,炎症媒介和共享风险因素.
主要成果:
- 口腔病原体可以导致呼吸系统疾病,牙斑充当储.
- SARS-CoV-2 可能存在于牙周口袋中,常见的炎症媒介 (IL-1,IL-6,CRP) 在PD和严重的COVID-19中都升高.
- 糖尿病,肥胖,衰老和男性性别等共同的风险因素对这两种情况都很重要.
结论:
- 牙周病似乎在加剧COVID-19中发挥着重要作用.
- 患有PD可能会对COVID-19患者的预后和死亡率产生负面影响.
- 对口腔全身链接的进一步研究是有必要的,以改善患者的结果.
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