在周围循环和癌症组织中的结肠直肠癌特异性微生物群
Shushan Yan1,2, Tie Liu3, Haobin Zhao4
1Department of Gastrointestinal and Anal Diseases Surgery, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
Frontiers in microbiology
|September 5, 2024
概括
结直肠癌 (CRC) 血清和组织中改变的肠道微生物群和特定的微生物种类显示出早期检测和预后的生物标志物的潜力. 这项研究确定了循环中的CRC特定细菌,为非侵入性诊断提供了新的途径.
科学领域:
- 微生物组研究的研究.
- 癌症生物学 癌症生物学
- 基因组学就是基因组学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 肠道微生物群和代谢物涉及CRC病变发生.
- 在CRC中瘤和循环微生物组的变化需要进一步调查.
研究的目的:
- 为了验证用于CRC检测的微生物生物标志物.
- 鉴定CRC患者血清和瘤组织中的微生物组变异.
- 评估转移对微生物组成的影响.
主要方法:
- 使用2bRAD测序进行微生物组 (2bRAD-M) 分析.
- 从CRC患者的血清和癌症组织中特征化的微生物组.
- 分析了微生物多样性 (α-多样性和β-多样性) 和组成.
主要成果:
- 血清和组织微生物组表现出不同的组成.
- 瘤和邻近的组织显示了类似的微生物群落.
- 观察到血清微生物群多样性的显著变化,特别是肝转移.
- 在血清中确定了CRC特有的微生物物种,包括Moraxella A cinereus,Flavobacterium sp001800905和Acinetobacter albensis.
- 确认了与CRC转移状态相关的复杂功能途径.
结论:
- 在CRC患者的微生物组成和多样性的显著变化.
- 确定了流通中的CRC特定微生物物种和组织作为潜在的诊断生物标志物.
- 特定于CRC的细菌种群具有个性化查,风险分层和改进的非侵入性诊断方法的潜力.
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