休息活动节律障碍与中风风险和中风后不良结果的关联
Lei Gao1,2,3,4, Xi Zheng2, Sarah N Baker1
1Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School Boston MA.
Journal of the American Heart Association
|September 5, 2024
概括
被打乱的24小时休息活动节奏与中风风险增加有关. 压抑或碎片化的节奏也可能预测中风后更糟糕的结果.
科学领域:
- 时间生物学 时间生物学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 循环时钟影响许多生物过程,并表现出24小时的节奏.
- 这些节律中断与中风风险之间的关系尚不清楚.
- 这项研究调查了24小时休息活动模式与中风风险之间的关联.
研究的目的:
- 评估24小时休息活动节奏与中风风险之间的关联.
- 为了确定节律障碍是否预测中风后的主要不良结果.
主要方法:
- 利用了来自英国生物库的100,000名参与者 (年龄在44-79岁之间) 的数据.
- 评估休息活动节奏使用动图在6-7天内.
- 在5年的中位数随访期间,采用了Cox对发生中风和中风后不良结果的比例危险模型.
主要成果:
- 抑制的相对幅度 (最低四分位数) 与61%的中风风险增加有关 (HR,1.61).
- 最活跃的10小时期间的晚期中点时间也与更高的中风风险相关 (HR,1.26).
- 分断的节奏 (更高的日内变化) 与增加中风风险 (HR,1.26) 和中风后不良结果 (HR,2.02) 有关.
结论:
- 压制的24小时休息活动节奏似乎是中风的重要危险因素.
- 节律碎片化可能是中风后主要不良结果的早期指标.
- 这些发现凸显了昼夜健康在预防心血管疾病方面的重要性.
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