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大脑储备和多发性硬化症临床发病时间

Maria Petracca¹, Serena Ruggieri¹, Riccardo Nistri¹

¹Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Multiple sclerosis (Houndmills, Basingstoke, England)

|September 5, 2024

概括

大脑储备的增加,由大脑体积的增加表明,可能会延迟多发性硬化症 (MS) 的临床发病. 这一发现表明大脑储备会影响生物发病后多发性硬化症症状的时间.

科学领域:

神经免疫学神经免疫学
神经学神经学
流行病学流行病学

背景情况:

多发性硬化症 (MS) 在生物和临床发病之间有潜伏期.
影响这种潜伏期的因素,特别是第一个临床事件的时间,尚不清楚.

研究的目的:

调查大脑储备是否影响多发性硬化症临床发病时间.
为了确定更大的最大终身大脑生长 (MLBG) 是否与延迟的MS发作有关.

主要方法:

对326名患有复发性MS的患者进行了事件时间分析.
使用内体积 (最大终身大脑生长) 来估计大脑储备.
使用了Cox比例危险回归,按性别分层,并根据MS风险因素进行调整.

主要成果:

发现大脑储备对疾病发病时间的显著保护作用 (HR = 0.11,p = 0.032).
即使在调整了病前多发性硬化症风险因素后,这种关联仍然很重要.

结论:

大脑储备可能在延迟MS临床表现方面发挥作用.
大脑储备的增加可能会抵消潜在的病理过程,推迟第一个临床症状.

关键词:

大脑储备储备是什么?多发性硬化症多发性硬化症开始发作开始发作预先开始的分娩预先开始的分娩风险因素风险因素自我报告的前发症.

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