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滑液滴用于治疗成人隐形眼镜不适的情况
Barbara Caffery1, Andrew D Pucker2, Ngozi C Chidi-Egboka3,4
1Toronto Eye Care, Toronto, Canada.
The Cochrane database of systematic reviews
|September 5, 2024
概括
与没有治疗相比,滑性眼滴可能会为隐形眼镜的不适提供一些缓解,但证据不确定. 需要进一步的研究来证实它们对隐形眼镜佩戴者的有效性和安全性.
科学领域:
- 眼科医生 眼科 眼科
- 临床试验 临床试验
- 眼睛表面疾病 眼睛表面疾病
背景情况:
- 隐形眼镜的不适影响了大量的隐形眼镜佩戴者,影响了佩戴时间,导致停止使用.
- 目前的治疗方法,包括滑液,缺乏有效性和安全性的强有力的证据.
- 眼睛表面的变化和梅博米腺功能障碍是隐形眼镜不适的相关症状.
研究的目的:
- 为了评估滑液滴对成人隐形眼镜佩戴者眼部不适的疗效和安全性.
- 为了比较没有处理的滑液和与盐溶液的滑液.
- 评估结果,如隐形眼镜的不适,角膜染色,结膜发红和不良事件.
主要方法:
- 进行了对平行组随机对照试验 (RCT) 的系统审查和元分析.
- 搜索包括多个数据库 (CENTRAL,MEDLINE,Embase.com) 和试验注册到2024年5月.
- 包括7项涉及463名成年参与者的RCT,比较滑液滴 (包括盐水) 与没有治疗或盐水.
主要成果:
- 与没有治疗相比,滑液滴可能会减少隐形眼镜的不适,但证据非常不确定.
- 有低确定性证据表明,在滑滴和不接受治疗之间,角膜染色或结膜发红的差异很小或不存在.
- 与盐水相比,滑液滴对不适感几乎没有影响,证据非常不确定. 在四周内没有报告任何视力威胁的不良事件.
结论:
- 非常低的确定性证据表明,滑液可能会改善隐形眼镜的不适,而不是没有治疗,但不是与盐水相比.
- 低确定性证据表明,滑液在短期使用 (1-4周) 中可能是安全的.
- 需要进一步进行高质量的试验,以证实患者报告的结果和滑剂滴对隐形眼镜不适的长期安全性.
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