非类固醇抗炎药物不会影响对运动的骨代谢反应
Jeffery S Staab1, Cara E Sczuroski1, Jess A Gwin2
1Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, MA.
Medicine and science in sports and exercise
|September 5, 2024
概括
非类固醇抗炎药物 (NSAID) 在强度炼后没有改变骨形成生物标志物. 剧烈的运动确实影响了骨代谢,但使用NSAID并没有改变这些反应.
科学领域:
- 运动生理学 运动生理学
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 非类固醇抗炎药物 (NSAID) 与增加压力骨折风险有关.
- 无 NSAID 可能会抑制骨对运动的适应性反应.
- 调查NSAID对骨形成生物标志物的影响至关重要.
研究的目的:
- 为了确定单次,最大剂量的三个不同的NSAID是否会改变骨形成生物标志物对艰苦运动的反应.
- 为了检查易布洛芬,塞莱科克西布和弗卢比布洛芬对骨代谢标记物的影响.
- 评估NSAID摄入量与运动诱导的骨适应之间的关系.
主要方法:
- 12名参与者进行了四次平度跳跃.
- 参与者在运动前2小时服用了安慰剂,易布洛芬 (800毫克),赛莱科西布 (200毫克) 或弗鲁比 (100毫克).
- 运动前和运动后采集了血液和尿液样本,以测量各种骨生物标志物和前列腺素E2代谢物.
主要成果:
- 运动显著影响了几种骨代谢生物标志物,包括1型公原N终端和骨素.
- 对于任何测量的骨生物标志物,没有观察到任何重要的NSAID治疗效果.
- 与安慰剂相比,所有NSAID组中的前列腺素E2代谢物水平显著降低.
结论:
- 压力测量运动显然改变了骨代谢标志物.
- 在炼前2小时服用NSAID并没有改变这些运动诱导的骨代谢反应.
- 这些发现表明,NSAID可能不会抑制急性适应性骨形成对运动的反应.
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