怀孕早期的血中含有和多基基物质 (PFAS) 和母亲中年肥胖症
Jordan A Burdeau1, Briana J K Stephenson2, Jorge E Chavarro1,3
1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA.
The Journal of clinical endocrinology and metabolism
|September 5, 2024
概括
在怀孕期间暴露于某些per-和多基基物质 (PFAS) 可能会影响长期的母体脂肪. 特定的PFAS显示了与中年体重和身体脂肪的不同关联.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 和多醇基物质 (PFAS) 暴露与心脏代谢疾病风险因素有关.
- 怀孕是内分泌干扰和评估PFAS对母亲健康影响的关键窗口.
- 关于孕期评估的PFAS对孕产妇肥胖的长期影响的研究有限.
研究的目的:
- 估计单个PFAS和PFAS混合物的早期怀孕水平与中年母亲肥胖之间的关联.
- 调查特定PFAS对长期身体成分的差异性影响.
主要方法:
- 对来自Project Viva的547名参与者进行了早期怀孕血PFAS测量的研究.
- 评估中年肥胖的结果,包括体重,腰围,干脂肪质量和总体脂肪质量.
- 线性回归和贝叶斯内核机器回归 (BKMR) 的应用用于统计分析.
主要成果:
- 更高的中年体重与增加的甲硫酸盐 (PFOS) 和2 - 乙烯-甲硫胺) 乙酸盐有关.
- PFOS与中年肥胖症呈正相关性,而 perfluorononanoate 和 perfluorohexane sulfonate 与几个肥胖症指标呈反相关性.
- 与整体PFAS混合物没有发现任何显著的关联.
结论:
- 在怀孕期间测量的特定PFAS可能对中年母亲的肥胖有不同的影响.
- 这些发现表明,某些PFAS对晚年母亲心脏代谢健康的潜在影响.
- 需要进一步的研究,以了解PFAS暴露对孕产妇健康的机制和长期影响.
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