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莱斯特咳问卷在成年人中具有耐火或无法解释的慢性咳的内容有效性:一种定性采访研究
Allison Martin Nguyen1, Carmen La Rosa1, Alexandra G Cornell1
1Merck & Co., Inc., Rahway, NJ, USA.
Therapeutic advances in respiratory disease
|September 5, 2024
概括
莱斯特咳问卷 (LCQ) 适用于评估耐性慢性咳 (RCC) 和不明原因慢性咳 (UCC) 患者的慢性咳影响. 这种患者报告的结果指标准确地捕捉了对生活在这些疾病中的人来说最重要的经历.
科学领域:
- 肺部病理学 肺部病理学
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 持续超过8周的慢性咳包括耐火性慢性咳 (RCC) 和无法解释的慢性咳 (UCC).
- 患者报告的结果 (PRO) 措施对于了解患者慢性咳的经验至关重要.
- 莱斯特咳问卷 (LCQ) 是一个现有的PRO,但其在RCC/UCC群体中的内容有效性尚未确定.
研究的目的:
- 评估19项莱斯特咳问卷 (LCQ) 在成年人中耐火性慢性咳 (RCC) 和无法解释的慢性咳 (UCC) 的内容有效性.
主要方法:
- 进行了一项横截面的定性采访研究.
- 现有的采访数据 (N=30) 被映射到LCQ概念中,临床专家审查了项目突出性.
- 半结构面试 (N=20) 涉及概念诱导和认知汇报,以评估LCQ对RCC/UCC患者的适当性.
主要成果:
- 从定性访谈中获得的概念与LCQ项目保持一致,捕捉了大多数"最烦人的"影响.
- 减少咳频率是所有参与者的关键治疗目标.
- 认知回顾显示了参与者的高度认可 (>=70%) 和对LCQ项目的理解,表明适当性.
结论:
- 这些发现支持LCQ对RCC/UCC患者的内容有效性.
- 已证明LCQ适用于评估最相关的咳影响.
- 这个PRO措施有效地捕捉了患有难治或无法解释的慢性咳的成年人的经历.
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