相关实验视频
Updated: Jul 13, 2026

09:22
Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
Published on: October 13, 2017
11.8K
在患有IgA血管炎与炎的儿童中,血清细胞因子 (cytokine) 概况
Yanyan Jin1, Xue He1, Weiqiang Lin2
1Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Biomolecules & biomedicine
|September 5, 2024
概括
研究人员确定了IgA血管炎与炎 (IgAVN) 的新生物标志物. CEACAM-5和ADAM12在IgAVN患者中显示出疾病严重程度和进展的指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 带有炎的IgA血管炎 (IgAVN) 是一种严重的疾病,需要有效的诊断和预后工具.
- 目前对IgAVN的诊断方法可能缺乏特异性和敏感性.
- 需要新的生物标志物来评估疾病的严重程度和监测疾病的进展.
研究的目的:
- 为了确定IgA血管炎与炎 (IgAVN) 的新型血清蛋白生物标志物.
- 验证组织中的潜在生物标志物,并将其与疾病特征相关联.
- 探索生物标志物与患者预后之间的关系.
主要方法:
- 从IgAV和IgAVN患者的血清进行定量平面蛋白微阵列分析.
- 在脏组织中使用半定量免疫光学验证差异表达蛋白质.
- 生物标志物表达与病理等级和预后之间的相关性分析.
主要成果:
- 在IgAVN和IgAV组之间,有41种蛋白质的表达差异.
- 在脏组织中检测到ADAM12,TIM-3,IL-12p40和CEACAM-5.
- ADAM12和CEACAM-5表达与IgAVN病理等级正相关.
- CEACAM-5显示出作为IgAVN预后生物标志物的潜力.
结论:
- CEACAM-5和ADAM12是评估IgAVN严重性的有希望的生物标志物.
- CEACAM-5可以作为监测IgAVN进展和预后的宝贵工具.
- 需要对更大的队列进行进一步的研究,以确认CEACAM-5的预后价值.
相关概念视频
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

