周水管灰色子区域的连接性及其与排尿欲望唤醒功能的关联
Shaogen Zhong1, Xindi Lin1, Mengxing Wang2
1Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dongfang Rd. Pudong District, Shanghai, 200127, China.
European child & adolescent psychiatry
|September 5, 2024
概括
患有初级夜间尿泡症 (PNE) 的儿童表现出大脑连接的改变. 排尿欲望唤醒 (MDA) 功能障碍与特定的大脑干和皮质功能连接性变化相关,影响膀控制.
科学领域:
- 神经科学是一个神经科学.
- 儿科泌尿外科 儿科泌尿外科
- 脑部成像 脑部成像
背景情况:
- 主要夜间尿尿症 (PNE) 与儿童的大脑干异常有关.
- 排尿前的兴奋反应与大脑功能连接之间的关系尚不清楚.
研究的目的:
- 为了研究排尿欲望唤醒 (MDA) 功能和中脑周水道灰色 (PAG) 的功能连接之间的相关性.
- 探索PAG的作用,一个关键的大脑干区域,在调节人类排尿.
主要方法:
- 获得了功能磁共振成像 (fMRI) 和来自133名患有PNE的儿童和40名健康对照的临床数据.
- 进行全脑相关性分析,以检查PAG子区域与大脑皮层之间的连接.
- 专注于与MDA功能范围的相关性.
主要成果:
- MDA功能障碍与左腹侧PAG (vlPAG) 和上旋的右极之间的静止状态功能连接 (RSFC) 有正相关.
- MDA 功能障碍与右侧vlPAG 和右侧上顶叶之间RSFC负相关.
- MDA 功能障碍显示,背中介PAG (dmPAG) 和右下侧顶叶之间与RSFC之间存在负相关性.
结论:
- 研究结果表明,由于功能连接受损,PAG内的膀膨胀信号受损.
- 这种干扰会影响执行功能,注意力和默认模式网络,导致唤醒和膀控制不良.
- 确定的神经点可以为PNE的未来治疗干预提供信息.
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