葡萄牙中部小型反动物肝炎E病毒的血清和分子调查
Sérgio Santos-Silva1, Jesús L Romalde2, Jaqueline T Bento3
1School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.
Food and environmental virology
|September 5, 2024
概括
肝炎E病毒 (HEV) 在葡萄牙绵羊和山羊中传播,发现了2%的血清流行率. 虽然在胆汁中没有检测到HEVRNA,但抗体表明过去的暴露,突出了潜在的公共卫生问题.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 公共卫生 公共卫生
- 病毒学 病毒学
背景情况:
- 肝炎E病毒 (HEV) 是一种新兴的公共卫生问题,主要通过食物传播途径 (HEV-3) 传播.
- 猪是动物性HEV基因型3的主要宿主,但其在小反动物中的流行需要调查.
研究的目的:
- 评估葡萄牙绵羊和山羊中HEV的循环和感染潜力.
- 在小反动物中确定HEV RNA存在和抗体血清流行率.
主要方法:
- 在葡萄牙中部 (2022年1月至2023年3月) 收集了400个胆汁和493个羊和山羊的血液样本.
- 利用嵌套宽频RT-PCR用于胆汁中HEVRNA检测.
- 采用商业的多种ELISA用于血液中检测抗HEV抗体.
主要成果:
- 在任何分析的胆汁样本中都没有检测到HEV RNA.
- 总体HEV抗体血清流行率为2% (山羊为2.2%,绵羊为2.0%).
- 在年龄,性别,物种和HEV血清流行之间没有发现显著的关联.
结论:
- 葡萄牙的小反动物显示出HEV暴露的证据,由抗体血清流行率表明.
- 需要进一步的研究,以了解这些物种中的HEV传播动态及其对公共卫生的影响.
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