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复杂配方中转皮醇的皮肤透和透特性^®

Jasmine Musakhanian¹, David W Osborne², Jean-David Rodier³

¹Senior Scientific Director, Paramus, USA. jasmine.musa@videotron.ca.

AAPS PharmSciTech

|September 5, 2024

概括

甲基二甲基醇单乙烯 (Transcutol®,TRC) 在各种复杂的配方中增强了药物通过皮肤的透. 本综述探讨了其机制以及影响通过皮肤递送的因素,以提高药物疗效.

科学领域:

制药科学制药科学
皮肤药物输送皮肤药物输送
配方科学科学配方科学

背景情况:

口服药物管理面临局限性,需要使用其他输送途径.
穿皮输送提供了一个替代方案,避免口服的缺点.
皮肤透增强剂,如醇溶剂,改善皮肤的被动扩散.

研究的目的:

探索乙烯糖醇单乙烯 (Transcutol®,TRC) 作为复杂配方系统中的皮肤透增强剂的作用.
讨论多组分配方中含有酒溶剂,特别是TRC的增强机制.
分析药物特性,皮肤屏障功能和配方参数的相互作用,以成功通过皮肤递送.

主要方法:

关于皮肤透增强剂的现有文献的审查,重点是烯基醇 (PG),乙醇 (EtOH) 和Transcutol® (TRC) 等水醇溶剂.
探索TRC在各种复杂配方中的作用:贴片,乳液,囊泡,固体脂质纳米颗粒和微/纳米乳液.
讨论管理皮肤透和透的基本原则,包括药物扩散,溶解,热力学活性和溶剂阻力.

主要成果:

在各种复杂的配方中,TRC显示出作为皮肤透增强剂的巨大潜力.
增强机制包括增加药物扩散,改善溶解和改变角层分区.
顺利的通过皮肤递送取决于药物特征,皮肤屏障特性和配方设计之间的协同相互作用.

结论:

乙甘醇单乙烯 (TRC) 是一种多功能增强剂,用于通过多种复杂配方通过皮肤递送药物.
了解作用机制和优化配方参数对于通过皮肤途径最大限度地提高治疗疗效至关重要.
本综述提供了有关利用TRC和其他酒溶剂用于先进的皮肤穿透药物输送策略的见解.

关键词:

机理机制机理机制通过皮肤的吸收.透透射是一种透的方法.皮肤皮肤皮肤皮肤通过切割 (Transcutol) 来解决问题.通过皮肤通过皮肤.

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