在急性和持续的lysergic acid diethylamide微剂后进行多式创意评估
Robin J Murphy1, Rachael L Sumner2, Kate Godfrey3
1School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. robin.murphy@auckland.ac.nz.
Psychopharmacology
|September 5, 2024
概括
在一项随机对照试验中,微剂量lysergic acid diethylamide (LSD) 并没有提高创造力. 客观措施显示没有急性或持久的影响,尽管主观报告增加了创造力.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 认知心理学 认知心理学
背景情况:
- 微剂量迷幻药物,特别是lysergic acid diethylamide (LSD),与增强的创造力有事联系.
- 在验证这些主观报告时,量化创造力是一个重大挑战.
- 对微剂量对创造力影响的客观评估至关重要.
研究的目的:
- 为了研究微剂量LSD对创造力的影响.
- 在随机对照试验 (RCT) 框架内利用多模式的创造力测试.
主要方法:
- 80名健康的成年男性参与了为期六周的RCT.
- 参与者每三天接受10μg剂量的LSD或安慰剂.
- 在基线,急性剂量和治疗后使用替代用途测试 (AUT),远程协同任务 (RAT),共识评估技术 (CAT) 和日常问题解决问卷 (EPSQ) 来评估创造力.
主要成果:
- 对于任何创造力指标 (AUT,RAT,CAT,EPSQ) 没有观察到显著的药物与时间相互作用.
- 基线词汇显著预测了AUT和RAT的表现.
- 对剂量日增加创造力的主观报告没有得到客观发现的支持.
结论:
- 微剂量LSD治疗方案没有对创造力产生急性或持久的客观影响.
- 对零结果的潜在解释包括实验室测试的局限性,当前创造力指标的不足或安慰剂效应.
- 需要进一步的研究来探索微剂量和创造力之间的复杂关系.
相关概念视频
Hallucinogens and Psychedelics
160
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
160
Altered States of Awareness
162
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
162
Cognitive Learning
233
Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
233
CNS Stimulants: Psychedelic Agents
132
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
132


