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在B细胞淋巴瘤中,SETD1B突变赋予了细胞灭亡耐药性和BCL2独立性

Ana Portelinha1, Shenqiu Wang1, Sara Parsa1

  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center , New York, NY, USA.

The Journal of experimental medicine
|September 5, 2024
PubMed
概括

在卵泡淋巴瘤 (FL) 和扩散大B细胞淋巴瘤 (DLBCL) 中,SETD1B突变会导致对BCL2抑制剂如Venetoclax的耐药性. 向KDM5脱甲基酶可以恢复这些耐药淋巴瘤的药物敏感性.

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