败血性休克中弗鲁德科尔提松剂量-反应关系:一项随机的II期试验
James Walsham1,2, Naomi Hammond3,4,5, Antje Blumenthal2
1Princess Alexandra Hospital, Brisbane, Australia.
Intensive care medicine
|September 5, 2024
概括
在败血性休克患者中,肠道fludrocortisone显示出可变的吸收,但没有改善休克分离时间. 各组的死亡率相似,这表明添加弗鲁多科蒂松的益处有限.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 重症监护室的重症监护室是重症监护室的重症监护室.
背景情况:
- 败血栓冲击管理通常涉及皮和皮.
- 在重症患者中,肠道fludrocortisone的最佳剂量和吸收尚不清楚.
研究的目的:
- 为了评估不同肠道fludrocortisone剂量与败血性休克患者的水皮质联合的疗效和药理动力学.
- 为了确定肠道fludrocortisone是否改善了冲击分辨率的时间.
主要方法:
- 一个多中心,开放标签的II期随机试验比较了单独的皮和皮,每天服用50,100或200微克的肠道皮,持续7天.
- 主要结局是冲击解消的时间;药理动力学研究评估了fludrocortisone的吸收.
主要成果:
- 在97%的患者中检测到肠道fludrocortisone,具有广泛的血度变化.
- 两组之间没有观察到对冲击分辨的时间有显著差异.
- 28天死亡率为24% (仅用皮),17% (50微克),11% (100微克) 和11% (200微克).
结论:
- 肠道fludrocortisone在大多数感染性休克患者中达到可检测的血水平,但吸收不一致.
- 添加肠道fludrocortisone到hydrocortisone并没有缩短冲击分辨的时间.
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