基于饮食的糖尿病风险评分和乳腺癌:SUN项目的前性评估
Inmaculada Aguilera-Buenosvinos1,2, Miguel A Martínez-González1,2,3,4, Andrea Romanos-Nanclares5
1Universidad de Navarra Departamento de Medicina Preventiva y Salud Pública, Pamplona, 31008, Spain.
Journal of physiology and biochemistry
|September 5, 2024
概括
糖尿病风险饮食可能会降低乳腺癌的风险,特别是在绝经前妇女和那些BMI较低的妇女中. 适度遵守基于饮食的糖尿病风险评分 (DDS) 显示出与整体和绝经前乳腺癌发病率有显著的反向关联.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 2型糖尿病 (T2D) 与乳腺癌风险增加有关,可能由胰岛素/IGF系统介导.
- 影响T2D风险的饮食模式也可能影响乳腺癌的发展.
研究的目的:
- 为了前性地评估基于饮食的糖尿病风险评分 (DDS) 与女性乳腺癌风险之间的关联.
- 调查与较低T2D风险相关的饮食是否也与乳腺癌发病率降低有关.
主要方法:
- 在SUN (Seguimiento Universidad de Navarra) 队列中对10,810名女性进行了前性队列研究.
- 在基线和10年随访时使用经过验证的136项FFQ评估的饮食摄入量.
- 通过医疗记录确认的乳腺癌诊断;DDS被分类为三角动物.
主要成果:
- 适度的坚持 (中间的DDS三位数) 与明显较低的整体乳腺癌风险 (HR=0.55) 和绝经前乳腺癌风险 (HR=0.26) 相关.
- 最高的DDS三位数没有显示出显著的关联.
- 逆相关性在BMI<25 kg/m2 (p-相互作用=0.029) 的女性中更强.
结论:
- 适度遵守DDS促进饮食与降低乳腺癌风险有关.
- 这种保护作用在绝经前妇女和体重指数较低的妇女中更为明显.
- 研究结果强调了抗糖尿病饮食模式在预防乳腺癌方面的潜在作用.
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