运动和非运动措施以及老年人日常体力活动的下降
Shahram Oveisgharan1,2, Tianhao Wang1,2, Jeffrey M Hausdorff1,3,4,5
1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.
JAMA network open
|September 5, 2024
概括
传感器衍生的移动性指标和运动变量解释了老年人身体活动的下降. 提高转动速度和手的灵敏度可能有助于维持日常活动水平.
科学领域:
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
- 公共卫生 公共卫生
背景情况:
- 在老龄化人口中,久坐不动的生活方式与不良健康结果有关.
- 识别身体活动下降的可修改风险因素对于公共卫生干预至关重要.
研究的目的:
- 为了确定传感器衍生的移动性指标是否与运动和非运动变量相结合,解释了老年人日常体力活动下降的差异.
- 测试这一假设,即移动性指标可以解释体育活动下降的不明原因变异.
主要方法:
- 一项纵向队列研究 (Rush Memory and Aging Project) 涉及650名老年人 (平均年龄为81.4岁).
- 使用手腕和腰部佩戴的传感器来记录身体活动和移动性 (32英尺的步行,定时上升和移动,平衡).
- 采用线性混合效应和回归模型来分析变量与体力活动下降率之间的关联.
主要成果:
- 每日体育活动在参与者中每年下降约16.8%.
- 腰部传感器衍生的移动性指标 (32英尺的步行,TUG测试) 和传统的运动变量解释了体力活动下降的最大差异.
- 当所有变量结合在一起时,转动速度和手的灵敏度与日常体力活动的下降有显著的关联.
结论:
- 传感器衍生的移动性指标和运动变量是老年人身体活动下降的关键预测指标,比非运动性指标更重要.
- 需要进一步的研究来确认针对转速和手的灵敏度的干预措施是否可以减缓身体活动的下降.
相关概念视频
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...


