人类乳头瘤病毒疫苗接种和人类乳头瘤病毒相关的癌症率
Victor Adekanmbi1,2, Itunu Sokale3,4, Fangjian Guo1,2
1Center for Interdisciplinary Research in Women's Health, School of Medicine, The University of Texas Medical Branch, Galveston.
JAMA network open
|September 5, 2024
概括
德克萨斯州需要有针对性的干预措施来提高人类乳头瘤病毒 (HPV) 疫苗接种率,特别是在德克萨斯州北部地区,疫苗接种覆盖率较低,与HPV相关的癌症发病率较高. 该战略旨在减少这些癌症的未来负担.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的癌症构成了重大的公共卫生挑战.
- 了解HPV疫苗接种和癌症发病率的地理差异对于德克萨斯州有效的干预设计至关重要.
研究的目的:
- 评估HPV疫苗接种启动和完成率的时间趋势和地理空间模式.
- 在德克萨斯州的县级和卫生服务区域 (HSR) 分析与HPV相关的癌症发病率.
主要方法:
- 使用德克萨斯州免疫注册表和SEER数据 (2006-2022) 进行基于人口的横截面研究.
- 对9-17岁个体的HPV疫苗接种率的分析.
- 对20岁及以上个体的HPV相关癌症发病率的分析.
主要成果:
- 在德克萨斯州各县观察到HPV疫苗接种率 (6.3%-77.6%) 和最新率 (1.6%-34.8%) 的显著差异.
- 与HPV相关的癌症发病率在女性中为0至154.2每10万,在男性中为0至60.1每10万.
- 北德克萨斯州 (HSRs 2/3和4/5N) 的HPV疫苗接种率较低,癌症发病率较高.
结论:
- 在德克萨斯州,HPV疫苗接种覆盖率和与HPV相关的癌症发病率存在地理差异.
- 建议有针对性的干预措施,重点是增加HPV疫苗接种率和在覆盖率低的地区完成疫苗接种.
- 解决这些差异可能有助于减轻HPV相关癌症的未来负担.
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