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Updated: Jun 14, 2025

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使用人类多能干细胞建模神经心脏生理和疾病:目前的进展和未来的前景

Hsueh-Fu Wu1,2, Charlotte Hamilton3, Harrison Porritt3,4,5

  • 1Center for Molecular Medicine, University of Georgia, Athens, Georgia, USA.

The Journal of physiology
|September 5, 2024
PubMed
概括

人类多能干细胞 (hiPSCs) 使新型模型能够研究心脏和自主神经系统的相互作用. 这些模型有助于理解神经心脏发育和疾病,以更好地治疗心血管疾病.

关键词:
自主神经系统自主神经系统心脏病学心脏病学心脏病学疾病建模 疾病建模人类多能干细胞干细胞神经心脏病学神经心脏病学

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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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