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在雌性小鼠中编程长期代谢功能障碍,通过对高脂肪高糖饮食的连续中度限制

Micah P Wildes^1,2,3, Deemantha G Fernando², Connie C Grobe⁴

¹Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

|September 5, 2024

概括

在雌性小鼠中,反复间歇性食物限制导致葡萄糖耐受性受损,饮食行为发生改变. 即使在恢复持续养后,这些变化仍然存在,这表明了长期的代谢后果.

科学领域:

代谢健康代谢健康
营养科学营养科学
动物模型动物模型

背景情况:

间歇性禁食有助于减肥和葡萄糖代谢.
粮食不安全与肥胖和心脏代谢问题有关,特别是在女性中.

研究的目的:

研究间歇性养对雌性小鼠能量平衡和葡萄糖耐受性的影响.

主要方法:

接受高脂肪,高糖饮食的雌性小鼠从断奶到第19周间歇性地受到食物限制.
评估了身体组成,能量平衡,葡萄糖耐受性和荷尔蒙水平.

主要成果:

间歇性食物限制在限制期间减轻体重和脂肪质量.
在重新养后,受限小鼠的食物摄入量和体重增加,葡萄糖耐受性受损.
趋势表明关键的食欲调节激素水平较低.

结论:

反复间歇性食物限制可以改变饮食行为,导致当食物自由可获得时,导致葡萄糖不耐受.
需要进一步的研究,以了解这些代谢变化的潜在机制.

关键词:

能源平衡的能量平衡.养行为养行为葡萄糖不耐受症是什么间歇性的卡路里限制.

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