在自身免疫神经肌肉疾病中,SARS-CoV-2疫苗接种后患者报告的日常功能
Koos P J van Dam1, Luuk Wieske1,2, Eileen W Stalman1
1Department of Neurology and Neurophysiology, Amsterdam Neuroscience, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, the Netherlands.
European journal of neurology
|September 5, 2024
概括
对于患有自身免疫神经肌肉疾病的患者来说,SARS-CoV-2疫苗接种是安全的,对日常功能没有影响. 这项研究证实了针对骨髓灰质炎和其他神经肌肉疾病的疫苗安全性.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 自免疫神经肌肉疾病在SARS-CoV-2疫苗接种方面引发了安全问题.
- 评估疫苗对日常功能的影响对于患者管理至关重要.
研究的目的:
- 为了比较SARS-CoV-2疫苗接种前后的自身免疫神经肌肉疾病患者的日常功能.
- 评估SARS-CoV-2疫苗在这个脆弱人群中的安全性.
主要方法:
- 一项前性观察队列研究,包括患有肌痛性肌痛症 (MG),CIDP,MMN和IIM的患者.
- 疾病特异性患者报告结果措施 (PROMs) 评估了基线和疫苗接种后长达12个月的功能.
- 回归模型分析了与疫苗接种相关的PROM得分的变化;对恶化的最小临床重要差异 (MCID) 进行了评估.
主要成果:
- 包括325名患者:包括137名MG,79名CIDP,43名MMN,66名IIM.
- 与非疫苗接种期间相比,与疫苗接种相关的日常功能得分没有显著差异.
- 在6%的MG患者和28%的CIDP患者中观察到MCID的恶化,报告的治疗变化很小.
结论:
- 在患有自身免疫神经肌肉疾病的患者中,SARS-CoV-2疫苗接种没有对日常功能产生不良影响.
- 这些发现支持SARS-CoV-2疫苗接种对于这些疾病患者的安全性.
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