在怀孕早期或2型糖尿病时使用甲福明与早产子症之间的关联
Maya Patel1, Ashley N Battarbee, Jerrie S Refuerzo
1University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina; University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama; UTHealth Houston McGovern Medical School, Baylor College of Medicine, and Texas Children's Hospital, Houston, and University of Texas Medical Branch Galveston, Galveston, Texas; Columbia University Irving Medical Center, New York, New York; University of South Carolina School of Medicine Greenville/Prisma Health-Upstate, Greenville, South Carolina; University of California, San Diego, San Diego, California; University of Pennsylvania Perelman School of Medicine and Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania; The Ohio State University College of Medicine and Wexner Medical Center, Columbus, Ohio; University of Mississippi Medical Center, Jackson, Mississippi; Indiana University School of Medicine Indianapolis, Indiana; Rutgers Health/Robert Wood Johnson Medical School, New Brunswick, New Jersey; Oregon Health & Science University Portland, Oregon; and Ochsner Health New Orleans, Louisiana.
在2型糖尿病怀孕中,母亲使用甲福明并没有降低早产子前症的发生率. 这项研究发现,甲福明与产前或心血管疾病风险生物标志物之间没有显著的关联.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 围产儿医学 围产儿医学
背景情况:
- 怀孕期间的2型糖尿病增加了孕妇和新生儿并发症的风险.
- 孕前是糖尿病怀孕的一个重要问题.
- 甲胺用于治疗2型糖尿病,但其在妊娠并发症中的作用需要进一步研究.
研究的目的:
- 评估母亲使用甲福明和早产期孕在患有早期妊娠或先前存在的2型糖尿病的妇女中使用甲福明的关系.
- 评估甲胺对与心血管疾病风险相关的特定血清生物标志物的影响.
主要方法:
- 对MOMPOD随机试验的二次分析.
- 参与者与胰岛素一起服用甲福尔或安慰剂.
- 分析了血清生物标志物和孕前发病率 (怀孕37周和34周之前).
主要成果:
- 甲胺的使用与早产前的发病率降低 (怀孕37周或34周之前) 并没有显著相关.
- 在甲福明和安慰剂组之间,血清生物标志物水平没有显著差异.
- 在37周前产前的调整后几率比为1.04 (95% CI,0.70-1.56).
结论:
- 在患有2型糖尿病的孕妇中,添加甲福林在胰岛素治疗中并不能降低早产前的风险.
- 孕产妇使用甲福明并没有显示与与心血管风险相关的血清生物标志物变化的相关性.
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